Deglycyrrhizinated licorice (DGL) is licorice root with glycyrrhizin removed — the compound responsible for licorice's blood pressure and potassium side effects — leaving a supplement studied mainly for its potential to support the stomach and esophageal lining. The proposed mechanism is that DGL may stimulate mucus production, which could help protect irritated tissue and support healing, rather than reducing acid production directly. Research specifically on DGL for reflux is limited and mixed compared to the evidence behind PPIs or H2 blockers, so it's generally considered a complementary option rather than a primary treatment. People typically take it as a chewable tablet before meals. Because herbal supplements aren't regulated as tightly as medications and can interact with other treatments, it's worth mentioning to a doctor before adding it, especially alongside prescription reflux medication.
