Digestive enzyme supplements are marketed broadly for digestive comfort, but their relationship with reflux specifically is more mixed than the marketing usually suggests.
The reasoning behind trying them
The idea is that enzymes may help break down food more efficiently, reducing the time food sits in the stomach and, in theory, reducing pressure and reflux risk. This logic applies more clearly to general indigestion and bloating than to reflux caused primarily by a weak LES, which enzymes don't directly address.
Where the evidence is thin
There isn't strong direct research showing digestive enzyme supplements reduce reflux specifically, as opposed to general digestive discomfort. Some people report feeling better, which may reflect a real individual benefit or may reflect other factors (placebo, or genuinely having an enzyme insufficiency that reflux and indigestion symptoms were both stemming from).
A reasonable way to evaluate them for yourself
If your symptoms are more about post-meal fullness and slow digestion than classic burning reflux, an enzyme supplement might be worth a cautious trial. If burning and regurgitation are the dominant symptoms, addressing the LES and acid directly (through established reflux treatments) is likely to be more effective than enzymes alone.
